Endocrine Abstracts

Patients: Nineteen acromegalic patients (8 females, 21-69 years-old, with macroadenoma, microadenoma or no evidence of pituitary tumor in 15, 2, 2, respectively) resistant to first generation somatostatin analogs (FG-SA) at high doses and/or intolerant to pegvisomant were switched to pasireotide LAR (PasLAR). Eleven had persistent disease after neurosurgery and two had also undergone radiosurgery (12 and 24 months before starting PasLAR). Six complained of acromegalic headache...

Introduction: Transsphenoidal surgery (TSS) is the first-choice treatment in Cushing’s disease (CD) with an immediate success rate of 70-80%. Unfortunately, due to the high rate of post-operative recurrences, CD patients require life-long surveillance. However, there is no consensus on how to follow these patients after TSS to early diagnose relapses. The aim of the study was to find reliable predictors of recurrence after neurosurgery in CD.Materia...

Non-alcoholic fatty liver disease (NAFLD) is becoming more common over the world. Its predisposition for evolving to cirrhosis and hepatocellular cancer, as well as its link to extrahepatic symptoms, puts patients and clinicians under a double burden. Several studies have found a link between NAFLD and many endocrinopathies, demonstrating a substantial bi-directional link between NAFLD and hypogonadism, in both men and women. In man with T2DM, NAFLD is linked to reduced total ...

Cushing’s syndrome (CS) is associated with a considerable risk of complications including thromboembolic events (TE). They occur mostly within the first 2–3 months postoperatively. When present before surgery, CS has high rates of perioperative mortality and morbidity. The benefit of steroidogenesis inhibitors after TE is not fully known. Furthermore, little guidance is available regarding TE assessment/management in CS. We report a case of a 34-year-old male admitte...

Introduction: Osteoporosis is the most frequent metabolic bone disease worldwide affecting primarily the senior population. The associated bone loss in combination with a decline in physical performance lead to increased incidence of falls and fragility fractures. Thus, improving physical performance is key to preventing osteoporotic fractures.Methods: A total of 140 participants were inrolled in a cross-sectional study. Secondary causes of osteoporosis ...

Introduction: Melatonin is a crucial hormone for controlling sleep rhythms and disruption of its natural secretory rhythmicity is considered to be one of the causes of type 2 diabetes mellitus. The MTNR1B gene encodes the melatonin receptor. Polymorphism rs10830963 in this gene shows an association with fasting blood glucose and impaired glucose tolerance. Current studies suggest that carriers of the minor allele G have a slightly shifted cycle of melatonin secretion toward a ...

Background: Women with diabetes mellitus type 1 (DMt1) are known to have a higher prevalence of reproductive disorders, including delayed menarche, menstrual cycle abnormalities and рolycystic ovary syndrome (PCOS)-like phenotype.Objective: To evaluate the menstrual cycle characteristics of women with type 1 diabetes mellitus as well as to compare them with healthy women of reproductive age.Methods and patients: The study inclu...

Introduction: Acromegaly is an endocrine disease associated with an abnormal growth-hormone (GH) and insulin-like growth factor 1 (IGF-1) excess. Multiple studies demonstrated an association between these factors and pathways that play a major role in tumor proliferation, survival and resistance to anti-cancer therapies in many human malignancies.Objectives: We wanted to study the incidence and types of tumors which are associated with Acromegaly.<p ...

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

Aim: One of the hallmarks of type 2 diabetes (T2D) is impaired beta cell function, which develops in part as a result of widespread cellular de-differentiation. The current state-of-the-art defines beta cells as a heterogeneous islet population, with the existence of individual subpopulations including specialised ‘pacemakers’. We sought here to understand how overexpression-induced beta cell maturity affects such heterogeneity, befo...